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| Titel |
Normal variations in the isotopic composition of metabolically relevant transition metals in human blood |
| VerfasserIn |
L. Van Heghe, C. Cloquet, F. Vanhaecke |
| Konferenz |
EGU General Assembly 2012
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| Medientyp |
Artikel
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| Sprache |
Englisch
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| Digitales Dokument |
PDF |
| Erschienen |
In: GRA - Volume 14 (2012) |
| Datensatznummer |
250068327
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| Zusammenfassung |
| Cu, Fe and Zn are transition metals with great catalytic, structural and regulating importance
in the human body. Hence, an aberrant metabolism of these elements can have serious
implications on the health of a person. It is assumed that, due to differences in
isotope fractionation, the isotopic composition of these elements in whole blood of
patients can be different from that in blood of healthy subjects. Therefore, isotopic
analysis of the element affected by the disease can be a promising approach for early
diagnosis.
A method for isotopic analysis of Cu, Fe and Zn in human whole blood was developed.
The simultaneous chromatographic isolation of these elements and the conditions for isotope
ratio measurement via multi-collector ICP – mass spectrometry (MC-ICP-MS) were
optimized.
So far, only whole blood of supposedly healthy volunteers (reference population) was
analyzed. Results for Fe confirmed the known differences in isotopic composition
between male and female blood. It is also shown that other parameters can have
influence as well, e.g., the isotopic composition of Zn seems to be governed by the diet. |
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