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| Titel |
Association of Biomarkers of Systemic Inflammation with Organic Components and Source Tracers in Quasi-Ultrafine Particles |
| VerfasserIn |
Ralph Delfino, Norbert Staimer, Thomas Tjoa, Mohammad Arhami, Andrea Polidori, Daniel Gillen, Michael Kleinman, James Schauer, Constantinos Sioutas |
| Konferenz |
EGU General Assembly 2011
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| Medientyp |
Artikel
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| Sprache |
Englisch
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| Digitales Dokument |
PDF |
| Erschienen |
In: GRA - Volume 13 (2011) |
| Datensatznummer |
250046626
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| Zusammenfassung |
| The evidences regarding the air pollutant components and their sources responsible for
associations between particle mass concentrations and human cardiovascular outcomes are
still not adequate. In one of our previous investigations, we demonstrated the associations
between circulating biomarkers of inflammation and mass concentrations of quasi-ultrafine
particles -¤ 0.25 μm in aerodynamic diameter (PM0.25) in a panel cohort study of 60
elderly subjects with coronary artery disease living in the Los Angeles Basin. The
objective of our present study is to reassess the biomarker associations with PM0.25
using new particle composition data. Plasma interleukin-6 (IL-6) and soluble tumor
necrosis factor-α receptor II (sTNF-RII) were used as the weekly biomarkers of
inflammation (n= 578). Exposures included indoor and outdoor community PM0.25
constituents [polycyclic aromatic hydrocarbons (PAHs), hopanes, n-alkanes, organic
acids, water-soluble organic carbon, and transition metals]. We analyzed the relation
between biomarkers and exposures with mixed-effects models adjusted for potential
confounders.
Indoor and outdoor PAHs (low-, medium-, and high-molecular-weight PAHs), followed
by hopanes (vehicle emissions tracer), were positively associated with biomarkers, but
other organic components and transition metals were not. sTNF-RII increased by
135 pg/mL [95% confidence interval (CI), 45–225 pg/mL], and IL-6 increased by
0.27 pg/mL (95% CI, 0.10–0.44 pg/mL) per interquartile range increase of 0.56
ng/m3outdoor total PAHs. Two-pollutant models of PM0.25 with PAHs showed that nominal
associations of IL-6 and sTNF-RII with PM0.25 mass were completely confounded by
PAHs. Vehicular emission sources estimated from chemical mass balance models
were strongly correlated with PAHs (R= 0.71). We conclude that traffic emission
sources of organic chemicals represented by PAHs are associated with increased
systemic inflammation and explain the associations with quasi-ultrafine particle mass. |
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